Endocrine Abstracts

Clinicians recognize patients persistently experience residual symptoms of thyrotoxicosis or hypothyroidism etc. despite having achieved circulating levels of TSH and FT4 within the conventional normal ranges. In fact, many pathological conditions affect preferred TSH and FT4. In addition, evidences indicate that the laboratory-quoted normal thyroid hormones as well as TSH reference range could not be always appropriate for everyone in clinical practice. In neonates, infants, ...

Conventionally, physicians adjust LT4 dose by clinical estimation based on their experiences and available guidelines; however, no computational algorithm exists to support their decisions. The objective of this study is to build an artificial decision support system utilizing fuzzy logic to propose a proper LT4 dosage regimen. We used THYROSIM software as the model of human thyroid hormone regulation to simulate a virtual thyroidectomized patient, setting the secretion rates ...

Introduction: The thyroid gland plays an important role in metabolism of human body. Abnormal growth of this gland is called Goiter. Iodine deficiency was thought to be the main cause of goiter. However, despite years of salt iodization, goiter continues to be a major public health, worldwide. As the thyroid gland is the most common organ affected by autoimmune diseases, it is suggested that autoimmunity can disturb thyroid function and develop to goiter. This study tries to i...

Background: Diabetes mellitus has various characteristics in different organs. Some of the most important signs and symptoms are seen in joints and musculoskeletal system.Objectives: This study was designed to evaluate the effect of body mass index (BMI) on rheumatologic presentations of diabetic patients in Gorgan, Northeast of Iran.Methods: This was descriptive-analytic study which was done on DM patients whom referred to endocri...

Introduction: The effects of diabetes mellitus (DM) on bone mineralization and osteoporosis is not well established. While reduction in bone mineral density in patients with type 1 diabetes is almost confirmed, effects of type 2 diabetes on bone health is still unclear. However in some studies bone mineral density (BMD) was suggested to be normal or elevated, epidemiological reports have shown an increased risk of fracture among patients with type 2 diabetes. This paper tries ...

Introduction: Osteoporosis is a multifactorial skeletal disease that is characterized by reduced bone mineral density (BMD). BMD values depend on several factors such as age, sex and age at menopause. The purpose of this study was to determine the prevalence and changes in BMD in Iranian patients.Methods: Three hundred patients were selected through random sampling technique in 2009. BMD was assessed by Norland machine at the lumbar and femoral neck. Wei...

Background: current studies reported that pregnancy in women with hypopituitarism is rare and several obestristics and endocrinologic complications must resolve for successful pregnancy among these women. Here we report one woman with hypopituitarism who became pregnant after hormonal replacement therapy.Method: A therapeutic strategy for 34 years old pregnant women as known case of pituitary surgery and completed pan hypopituitarism was designed. We per...